specifies that intrathecal induction treatment consist of two injections per week for 4 weeks, a consolidation treatment of one injection per week for 4 weeks, and a maintenance treatment of one injection per month until disease progression. Concurrent use of intra-CSF methotrexate and radiation therapy Cited by: Sep 01, · Despite its numerous complications, intrathecal (IT) chemotherapy remains a longstanding treatment for leptomeningeal carcinomatosis. Using case studies with internationally reported results, we attempted to determine the necessity of IT chemotherapy Cited by: 9.
Introduction. Leptomeningeal carcinomatosis (LM) is a debilitating and rapidly progressing manifestation of solid tumors whose incidence is increasing [1–5].Although LM may develop in any cancer, breast cancer (half of cases), lung cancer, and melanoma are the most common primaries [6–10].Even when maximal standard therapy is tolerated (intrathecal Cited by: 6. Dec 01, · As to the treatment of LMC, it is generally accepted that the standard therapy involves introducing chemotherapeutic agents directly into the CSF (i.e. intrathecal or intraventricular chemotherapy) Cited by:
Purpose: Leptomeningeal disease is a rare presentation of advanced metastatic breast cancer. The purpose of this study was to evaluate craniospinal progression between intrathecal (IT) trastuzumab, IT chemotherapy, and whole brain radiation therapy (WBRT) in leptomeningeal virginxx.xyz by: 6.