Hypophosphatasia | Genetic and Rare Diseases Information. Feb 01, · Adult forms of hypophosphatasia are characterized by a softening of the bones known as osteomalacia. In adults, recurrent fractures in the foot and thigh bones can lead to .
Adults with hypophosphatasia experience a large number of fractures (mean [standard deviation, SD] of  fractures [range, ]). 15,b Pain and impaired mobility . Hypophosphatasia (HPP) is a rare inherited disorder of bone affecting approximately to known individuals in the United States. HPP is the result of mutations involving the gene Cited by:
Adult hypophosphatasia characterized by stress fractures and pseudofractures of the lower extremities in middle age, sometimes associated with early loss of adult dentition. .